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Kocot KM, Poustka AJ, Stöger I, Halanych KM, Schrödl M. New data from Monoplacophora and a carefully-curated dataset resolve molluscan relationships. Sci Rep. 2020 Jan 9;10(1):101.

doi: 10.1038/s41598-019-56728-w.

Hogan JD, Keenan JL, Luo L, Ibn-Salem J, Lamba A, Schatzberg D, Piacentino ML, Zuch DT, Core AB, Blumberg C3, Timmermann B, Grau JH, Speranza E, Andrade-Navarro MA, Irie N, Poustka AJ, Bradham CA.The developmental transcriptome for Lytechinus variegatus exhibits temporally punctuated gene expression changes. Dev Biol. 2020 Apr 15;460(2):139-154. doi: 10.1016/j.ydbio.2019.12.002. Epub 2019 Dec 6.




Ciușdel, CF, Coman S, Boldișor C, Kessler T, Muradyan A, Kovachev A, Lehrach H, Wierling C, Itu LM.
Effect of Linearization in a WNT Signaling Model. Computational and Mathematical Methods in Medicine, 2019 Jun 10. 2019:8461820. doi: 10.1155/2019/8461820.


Philippe H, Poustka AJ, Chiodin M, Hoff KJ, Dessimoz C, Tomiczek B, Schiffer PH, Müller S, Domman D, Horn M, Kuhl H, Timmermann B, Satoh N, Hikosaka-Katayama T, Nakano H, Rowe ML, Elphick MR, Thomas-Chollier M, Hankeln T, Mertes F, Wallberg A, Rast JP, Copley RR, Martinez P, Telford MJ.Mitigating Anticipated Effects of Systematic Errors Supports Sister-Group Relationship between Xenacoelomorpha and Ambulacraria. Curr Biol. 2019 Jun 3;29(11):1818-1826.e6. doi: 10.1016/j.cub.2019.04.009. Epub 2019 May 16.

Gu W, Yildirimman R, Van der Stuyft E, Verbeeck D, Herzinger S, Satagopam V, Barbosa-Silva A, Schneider R, Lange B, Lehrach H, Guo Y, Henderson D, Rowe A; IMI OncoTrack and the IMI eTRIKS consortia.Data and knowledge management in translational research: implementation of the eTRIKS platform for the IMI OncoTrack consortium. BMC Bioinformatics. 2019 Apr 1;20(1):164. doi: 10.1186/s12859-019-2748-y.


Fröhlich F, Kessler T, Weindl D, Shadrin A, Schmiester L, Hache H, Muradyan A, Schütte M, Lim JH, Heinig M, Theis FJ, Lehrach H, Wierling C, Lange B, Hasenauer J.Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model. Cell Syst. 2018 Dec 26;7(6):567-579.e6. doi: 10.1016/j.cels.2018.10.013. Epub 2018 Nov 28.

Devulapally PR, Bürger J, Mielke T, Konthur Z, Lehrach H, Yaspo ML, Glökler J, Warnatz HJ.Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes. Genome Med. 2018 Apr 27;10(1):34. doi: 10.1186/s13073-018-0542-5.


Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M et al., Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors. Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262.

Simeonov PL, Gare A, Matsuno K, Igamberdiev AU, Noble D. The Western and Eastern thought traditions for exploring the nature of mind and life. Prog Biophys Mol Biol. 2017 Dec;131:1-11. doi: 10.1016/j.pbiomolbio.2017.10.007.

Simeonov PL. Towards a first implementation of the WLIMES approach in living system studies advancing the diagnostics and therapy in augmented personalized medicine. Biosystems. 2017 Dec;162:177-204. doi: 10.1016/j.biosystems.2017.10.001.

Simeonov PL, Ehresmann AC. Some resonances between Eastern thought and Integral Biomathics in the framework of the WLIMES formalism for modeling living systems. Prog Biophys Mol Biol. 2017 Dec;131:193-212. doi: 10.1016/j.pbiomolbio.2017.05.014.


Stöger I, Kocot KM, Poustka AJ, Wilson NG, Ivanov D, Halanych KM, Schrödl M. Monoplacophoran mitochondrial genomes: convergent gene arrangements and little phylogenetic signal. BMC Evol Biol. 2016 Dec 16;16(1):274.


Lehrach H Omics approaches to individual variation: modeling networks and the virtual patient. Dialogues Clin Neurosci. 2016 Sep;18(3):253-265.

Broecker F, Horton R, Heinrich J, Franz A, Schweiger MR, Lehrach H, Moelling K. The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation. Mob DNA. 2016 Dec 7;7:25. eCollection 2016.

Broecker F, Hardt C, Herwig R, Timmermann B, Kerick M, Wunderlich A, Schweiger MR, Borsig L, Heikenwalder M, Lehrach H, Moelling K. Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line. FEBS J. 2016 May;283(9):1669-88. doi: 10.1111/febs.13694.

Grau JH, Nuñez JJ, Plötner J, Poustka AJ. The complete mitochondrial genome of Telmatobufo australis (Amphibia: Anura: Calyptocephalellidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Jul;27(4):2817-8. doi: 10.3109/19401736.2015.1053082.




Ogilvie LA, Wierling C, Kessler T, Lehrach H, Lange BMH (2015) Predictive Modeling of Drug Treatment in the Area of Personalized Medicine. Cancer Informatics 14(S4) 95–103



Lehrach H. Virtual clinical trials, an essential step in increasing the effectiveness of the drug development process. Public Health Genomics 2015, 6, In Press.


Wierling C, Kessler T, Ogilvie LA, Lange BM, Yaspo ML, Lehrach H. (2015) Network and systems biology: essential steps in virtualising drug discovery and development. Drug Discov Today Technol.;15:33-40 Lehrach, H.

Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ et al., Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015 Sep;47(9):1020-1029. doi: 10.1038/ng.3362. Epub 2015 Jul 27.


Perea-Atienza E, Gavilán B, Chiodin M, Abril JF, Hoff KJ3, Poustka AJ4, Martinez P5. The nervous system of Xenacoelomorpha: a genomic perspective. J Exp Biol. 2015 Feb 15;218(Pt 4):618-28. doi: 10.1242/jeb.110379.


Simeonov PL, Rosen SM, Gare A, Noble D. Editorial. Prog Biophys Mol Biol. 2015 Dec;119(3):208-17. doi: 10.1016/j.pbiomolbio.2015.09.003.






Henderson D, Ogilvie LA, Hoyle N, Keilholz U, Lange B, Lehrach H, on behalf of the OncoTrack Consortium (2014). OncoTrack: Personalized medicine approaches for colon cancer driven by genomics and systems biology. Biotechnology J. 9(9):1104-14.

Pandey V, Sultan M, Kashofer K, Ralser M, Amstislavskiy V, Starmann J, Osprian I, Grimm C, Hache H, Yaspo ML, Sültmann H, Trauner M, Denk H, Zatloukal K, Lehrach H, Wierling C. Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains.  PLoS One. 2014 Oct 27;9(10):e111006. doi: 10.1371/journal.pone.0111006. eCollection 2014.

Kaehler C, Isensee J, Hucho T, Lehrach H, Krobitsch S. 5-Fluorouracil affects assembly of stress granules based on RNA incorporation. Nucleic Acids Res. 2014 Jun;42(10):6436-47. doi: 10.1093/nar/gku264.





Barann M, Esser D, Klostermeier UC, Lappalainen T, Luzius A, Kuiper JW, Ammerpohl O, Vater I, Siebert R, Amstislavskiy V, Sudbrak R, Lehrach H, Schreiber S, Rosenstiel P. (2013) Janus - a comprehensive tool investigating the two faces of transcription. Bioinformatics 1;29(13), 1600-1606.


Linke C, Klipp E, Lehrach H, Barberis M, Krobitsch S. (2013) Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions. Front Physiol. 4, 173.


Lehrach H (2013) DNA sequencing methods in human genetics and disease research. F1000Prime Rep. eCollection 2013 5, 34.





The 1000 Genomes Project Consortium (2012) An integrated map of genetic variation from 1,092 human genomes. Nature 491,56–65.



Jozefczuk J, Kashofer K, Ummanni R, Henjes F, Rehman S, Geenen S, Wruck W, Regenbrecht C, Daskalaki A, Wierling C, Turano P, Bertini I, Korf U, Zatloukal K, Westerhoff HV, Lehrach H, Adjaye J (2012) A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells. Front Physiol. 3, 339.




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